85 Results for "

Veratrum nigrum Linn.

" in MedChemExpress (MCE) Product Catalog:
Products (85)

85 Results for "Veratrum nigrum Linn." in MCE Product Catalog:

53
Silvestrol
Silvestrol
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53 Publications Verification
Referencia número: HY-13251
No. CAS: 697235-38-4
Pureza:  99.96%
Synonyms: (-)-Silvestrol
Category:  

Agave americana Linn. Natural Products Agavaceae Plants Disease Research Fields Cancer

Target:  

Eukaryotic Initiation Factor (eIF) Apoptosis Autophagy

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis .
14
Morusin
Morusin
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14 Cited Publications
Referencia número: HY-N0622
No. CAS: 62596-29-6
Synonyms: Mulberrochromene
Category:  

Infection other families Flavonoids Anti-aging Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB STAT Bacterial

Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.
12
Vitexin
Vitexin
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12 Cited Publications
Referencia número: HY-N0013
No. CAS: 3681-93-4
Category:  

Cardiovascular Disease Neurological Disease Anti-aging Flavones Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Trigonella foenum-graecum Linn. Cancer

Target:  

Autophagy

Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .
11
Hematoxylin
Hematoxylin
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11 Cited Publications
Referencia número: HY-N0116
No. CAS: 517-28-2
Synonyms: Natural Black 1; Haematoxylin
Category:  

Leguminosae Caesalpinia sappan L. Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Amyloid-β

Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC50 of 1.6 μM.
10
Isobavachalcone
Isobavachalcone
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10 Cited Publications
Referencia número: HY-13065
No. CAS: 20784-50-3
Pureza:  99.01%
Synonyms: Corylifolinin; Isobacachalcone
Category:  

Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy

Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .
4
Asparagusic acid
Asparagusic acid
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4 Cited Publications
Referencia número: HY-50730
No. CAS: 2224-02-4
Category:  

Infection Liliaceae Ketones, Aldehydes, Acids Plants Disease Research Fields Asparagus officinalis L.

Target:  

Parasite Endogenous Metabolite

Asparagusic acid is a sulfur-containing flavor component produced by Asparagus officinalis Linn., with anti-parasitic effect. Asparagusic acid is a plant growth inhibitor .
3
α-Solanine
α-Solanine
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3 Cited Publications
Referencia número: HY-N6602
No. CAS: 20562-02-1
Category:  

Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer Steroids

Target:  

Apoptosis Autophagy Akt mTOR MMP NO Synthase COX NF-κB

α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells .
3
Jervine
Jervine
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3 Cited Publications
Referencia número: HY-N0836
No. CAS: 469-59-0
Synonyms: 11-Ketocyclopamine
Category:  

Alkaloids Piperidine Alkaloids Veratrum nigrum Linn. Liliaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Hedgehog Smo

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .
3
Khasianine
Khasianine
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3 Cited Publications
Referencia número: HY-N2322
No. CAS: 32449-98-2
Category:  

Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer

Target:  

Others

Khasianine is a steroidal glycoalkaloid which is obtained from black nightshade (Solanum Nigrum L.), which displays antitumor activity.
2
Methyl vanillate
Methyl vanillate
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2 Cited Publications
Referencia número: HY-75342
No. CAS: 3943-74-6
Category:  

Microorganisms Monophenols Oryza sativa Linn. Gramineae Phenols Plants

Target:  

Wnt Reactive Oxygen Species (ROS) Endogenous Metabolite

Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
2
Moracin O
Moracin O
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2 Cited Publications
Referencia número: HY-N3244
No. CAS: 123702-97-6
Category:  

Neurological Disease Phenols Polyphenols Plants Moraceae Disease Research Fields Inflammation/Immunology Morus alba Linn.

Target:  

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)

Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects .
1
Delphinidin 3-rutinoside chloride
Delphinidin 3-rutinoside chloride
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1 Cited Publications
Referencia número: HY-114367
No. CAS: 15674-58-5
Pureza:  98.83%
Synonyms: Delphinidin 3-O-rutinoside chloride
Category:  

Anthocyans Flavonoids Solanum melongena L. Phenols Polyphenols Plants Solanaceae Disease Research Fields Cancer

Target:  

Endothelin Receptor NO Synthase Myosin GLP Receptor

Delphinidin 3-rutinoside chloride is an anthocyanin component. Delphinidin 3-rutinoside chloride is isolable from the fruits of blackcurrant Ribes nigrum L. Delphinidin 3-rutinoside chloride activates the ETB receptor and stimulates the NO/cGMP pathway. Delphinidin 3-rutinoside chloride increases cyclic guanosine monophosphate production and reduces the phosphorylation level of Myosin regulatory light chain. Delphinidin 3-rutinoside chloride stimulates GLP-1 secretion. It significantly induces relaxation of bovine ciliary muscle strips contracted by ET-1 and inhibits ET-1-induced contraction of bovine ciliary muscle strips. Delphinidin 3-rutinoside chloride is applicable to research related to type 2 diabetes .
1
Arnidiol
Arnidiol
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1 Cited Publications
Referencia número: HY-N4165
No. CAS: 6750-30-7
Category:  

Triterpenes Terpenoids Dendranthema morifolium (Ramat.) Tzvel. Other Diseases Plants Compositae Disease Research Fields

Target:  

Others

Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F. .
1
Verazine
Verazine
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1 Cited Publications
Referencia número: HY-N11911
No. CAS: 14320-81-1
Synonyms: (-)-Verazine
Category:  

Alkaloids Other Alkaloids Veratrum maackii Regel Plants Melanthiaceae

Target:  

Fungal

Verazine ((-)-Verazine) is an anti-Fungal Agent that can be found in the dried roots and rhizoma of Veratrum maackii Regel. Verazine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. Verazine can be used in the study of fungal infections and neurological diseases .
1
3-Epioleanolic acid
3-Epioleanolic acid
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1 Cited Publications
Referencia número: HY-N4290
No. CAS: 25499-90-5
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

3-Epioleanolic acid is an active component of Verbena officinalis Linn, with anti-inflammatory activity .
1
Vitexin (Standard)
Vitexin (Standard)
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1 Cited Publications
Referencia número: HY-N0013R
No. CAS: 3681-93-4
Category:  

Flavonoids Leguminosae Flavones Phenols Polyphenols Plants Trigonella foenum-graecum Linn.

Target:  

Reference Standards Autophagy

Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .
Protodioscin
Protodioscin
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Referencia número: HY-N0799
No. CAS: 55056-80-9
Category:  

Leguminosae Plants Endogenous metabolite Disease Research Fields Trigonella foenum-graecum Linn. Cancer Steroids

Target:  

Endogenous Metabolite

Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
Prosapogenin A
Prosapogenin A
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Referencia número: HY-N6940
No. CAS: 19057-67-1
Synonyms: Progenin III
Category:  

Veratrum nigrum Linn. other families Liliaceae Plants Disease Research Fields Cancer Steroids

Target:  

Apoptosis Caspase Pyroptosis STAT

Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .
Dalbergin
Dalbergin
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Referencia número: HY-N8347
No. CAS: 482-83-7
Category:  

Dalbergia odorifera T. Chen Monophenols Leguminosae Other Diseases Coumarins Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Apoptosis

Dalbergin is a composition of the extract from the Dalbergia Sissoo Linn. knot wood. Dalbergin demonstrats notable antioxidant ability .
Pellitorine
Pellitorine
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Referencia número: HY-N3097
No. CAS: 18836-52-7
Category:  

Alkaloids Other Alkaloids Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Cancer Agricultural Research

Target:  

TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial

Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .
Assay Types